Discovering the basis of speciation, selection and genomic conflict

THE PHADNISTAS

LAB ALUMNI

POSTDOCTORAL FELLOWS

UNDERGRADUATE RESEARCHERS

DR. KIMBERLY FRIZZELL, Ph.D.

Now working as a scientist at ARUP Laboratories

ALYSSA BLACK

Now a graduate student at the University of Virginia in the Biology Ph.D. program

JOSIANA GOODMAN

Now a dentistry student at the University of Utah School of Dentistry

GRADUATE STUDENTS

NORA BROWN

Now a graduate student at the Cornell

RESEARCH TECHNICIANS

ALYSHA SCHEELER

Now utilizing her degree in health promotion in Indiana  while working towards medical school

RANDEE YOUNG

Now a graduate student at the University of California, San Diego in the genetics Ph.D. program

CHRIS LARGE

Now a graduate student at the University of Washington in the molecular biology Ph.D. program

HIGHSCHOOL RESEARCHERS

PREVIOUS ROTATION STUDENTS

Lincoln Gay

Samantha Hill

Rodrigo Costa

Tommy Carter

Deeptha Vasudevan

 

Rufino Rodriguez

Clayton Carey

Rachel Cosby

 

FRANCES WILLBERG

Now an undergraduate at the University of Arizona

WHAT WE STUDY

PUBLICATIONS

Cooper JC, Phadnis N. 2017. Parallel evolution of sperm hyper-activation Ca2+ channels. bioRxiv:120758. (pre-print)

 

 

Cooper, J. C. & Phadnis, N. A genomic approach to identify hybrid incompatibility genes. Fly (2016).

 

Phadnis, N., Baker, E.P., Cooper, J.C., Frizzell, K., Hseih, E., de la Cruz, A.F., Shendure, J, Kitzman, J., and Malik, H.S. (2015)  An essential cell cycle regulation gene causes hybrid inviability in Drosophila. Science, 350: 1552-1555.

Lee, J.E., Oney, M., Frizzell, K., Phadnis, N., Hollien, J. (2015) Drosophila melanogaster Activating transcription factor 4 Regulates Glycolysis during Endoplasmic Reticulum Stress. G3 doi: 10.1534/g3.115.017269.

Phadnis, N. and Malik, H.S. (2014) Speciation via autoimmunity: a dangerous mix. Cell doi:10.1016/j.cell.2014.11.028.

Phadnis, N. and Malik, H.S. (2013) The molecular and evolutionary basis of hybrid sterility: from Odysseus to Overdrive. Book chapter, ‘Speciation: Natural Processes, Genetics and Biodiversity’. Nova Publishers.

Phadnis, N., Hsieh, E. and Malik, H.S. (2011) Birth, death and replacement of karyopherins in Drosophila. Molecular Biology and Evolution doi:10.1093/molbev/msr306.

Phadnis, N. (2011) Genetic architecture of male sterility and segregation distortion in Drosophila pseudoobscura Bogota-USA hybrids. Genetics 189 (3):1001-1009.

Oliver, P.L., Goodstadt L, Bayes JJ, Birtle, Z., Roach KC, Phadnis, N, Beatson SA, Lunter, G, Malik, H.S., Ponting, C.P. (2009) Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genetics, Dec; 5(12):e1000753.

Phadnis, N. and Orr, H.A. (2009) A single gene causes both male sterility and segregation distortion in Drosophila hybrids. Science, 323: 376-378.

Orr, H.A., Masly, J.P and Phadnis, N. (2007) Speciation in Drosophila: from genes to molecules. Journal of Heredity 98(2): 103-110

Phadnis, N. and Fry, J.D. (2005) Widespread correlations between dominance and homozygous effects of mutations: Implications for theories of dominance. Genetics 171: 385-392.

Fry, J.D., Bahnck, C.M., Mikucki, M., Phadnis, N., and W.C. Slattery. (2004) Dietary ethanol mediates selection on aldehyde dehydrogenese activity in Drosophila melanogaster. Integrative and Comparative Biology 44:275-283.

Watve, M., Shejval, V., Sonawane, C., Rahalkar, M., Matapurkar, A., Shouche, Y., Patole, M., Phadnis, N., Champhenkar, A., Damle, K., Karandikar, S., Khirsagar, V. and Jog, M. (2000) The ‘K’ selected oligophilic bacteria: a key to uncultured diversity? Current Science 78:1535-1542.

NEWS

OUR COMMUNITY

At the University of Utah we have numerous resources and programs to help our students succeed.

Bioscience Ph.D. Program

The Bioscience Ph.D program at the University of Utah facilitates the entry and training of Ph.D students through a range of disciplines in the biological sciences. It serves as a source of intellectual diversity for both students and the labs they work in. The Program coordinates activities such as student recruiting and admissions, academic advising, career development,  curriculum, and social events.

Biology Department

The Department of Biology offers opportunities to learn, work, and collaborate across levels of biological organization and styles of research. Faculty research interests span the complete spectrum of biological phenomena and disciplines, from biochemistry to global environmental change.

Genetics Training Grant

The University of Utah has a proud tradition in research in genetics, which has by the Training Program in Genetics, funded by the National Institutes of Health for more than thirty years. The Training Program in Genetics and students trained by this program contributed to landmark discoveries in genetics, including discovery of restriction fragment length polymorphisms, development of a genetic linkage map in humans, and methods for targeted gene disruption in vertebrates.

EVOLUTION COMMUNITY

WHAT WE DO FOR FUN

 

CONTACT US

Location

Our lab is located on lower campus, in South Biology (BLDG 084), room 212

Phone

Lab: (801) 587-3916

Office: (801) 585-0493

Address:

Department of Biology, University of Utah

257 South 1400 East

Salt Lake City, UT 84112

PEOPLE

RESEARCH

PUBLICATIONS

COMMUNITY

MEDIA

CONTACT

NEWS